Well, sir, let us do what we can to curtail this visit, which can hardly be agreeable to you, and is inexpressibly irksome to me..

I think you want a little unofficial help. Three undetected murders in one year won't do, Lestrade. But you handled the Molesey Mystery with less tha….

This looks like one of those unwelcome social summonses which call upon a man either to be bored or to lie..

The unexpected has happened so continually in my life that it has ceased to deserve the name..

The less experienced a doctor is, the higher are his notions of professional dignity . . ..

His neighbor is a tooth-drawer. That bag at his girdle is full of the teeth that he drew at Winchester fair. I warrant that there are more sound ones….

Exactly. She does not shine as a wife even in her own account of what occurred. I am not a whole-souled admirer of womankind, as you are aware, Watso….

The larger crimes are apt to be the simpler, for the bigger the crime, the more obvious, as a rule, is the motive..

No man burdens his mind with small matters unless he has some very good reason for doing so..

Great sorrow or great joy should bring intense hunger--not abstinence from food, as our novelists will have it..

The more outré and grotesque an incident is the more carefully it deserves to be examined..

By a man's finger-nails, by his coat-sleeve, by his boots, by his trouser-knees, by the callosities of his forefinger and thumb, by his expression, b….

To let the brain work without sufficient material is like racing an engine. It racks itself to pieces..

"There are one or two elementary rules to be observed in the way of handling patients," he remarked, seating himself on the table and swinging his le….

The good Watson had at that time deserted me for a wife, the only selfish action I can recall in our association. I was alone..

Critics kind never mind! Critics flatter no matter! Critics blame all the same! Do your best damn the rest!.

What one man can invent, another can discover..

Just see how it glints and sparkles. Of course it is a nucleus and focus of crime. Every good stone is. They are the devil.

I must apologize for calling so late," said he, "and I must further beg you to be so unconventional as to allow me to leave your house presently by s….

There is a soul-jealousy that can be as frantic as any body-jealousy..

You know my methods. Apply them..