Vinod Khosla

I've probably failed more often than anybody else in Silicon Valley. Those don't matter. I don't remember the failures. You remember the big successes.

Seeking an acquisition from the start is more than just bad advice for an entrepreneur. For the entrepreneur it leads to short term tactical decisions rather than company-building decisions and in my view often reduces the probability of success.

Is it 10 years, 20, 50 before we reach that tipping point where climate change becomes irreversible? Nobody can know. There's clearly a probability distribution. We need to ensure this planet, and we need to do it quickly.

Entrepreneurs have the flexibility and the ability to do things that large companies simply cannot. Could a large company pull off a trick like Amyris, going from anti-malaria medicine to next-generation fuel?

The only way you multiply resources is with technology. To really affect poverty, energy, health, education, or anything else - there is no other way.

You need a degree of foolishness to cause disruptive change in healthcare. Dare to dream.

Did Google know much about media? Or Amazon about commerce? Tesla about cars? SpaceX about rockets? EBay about classifieds? What did I know about computing when I started Sun Microsystems? We should celebrate these entrepreneurs, not pillory them for fighting entrenched incumbent industries that have political influence and money.