When I was a college student at Yale, I was studying physics and mathematics and was absolutely intent on becoming a theoretical physicist.

- James Rothman

I started taking a basic biology course, and I really loved it. I started asking research questions incessantly. I was drawn very quickly to biology.

- James Rothman

I had five years of failure, really, before I had the first initial sign of success.

- James Rothman

I became aware of the very complex internal organization in a cell from the basic science classes, and it made me think about how all that could work…

- James Rothman