It is easy to obtain confirmations, or verifications, for nearly every theory-if we look for confirmations. Confirmations should count only if they are the result of risky predictions... A theory which is not refutable by any conceivable event is non-scientific. Irrefutability is not a virtue of a theory (as people often think) but a vice. Every genuine test of a theory is an attempt to falsify it, or refute it.
Interpretation
The quote emphasizes the importance of falsifiability in scientific theories over mere confirmations.
Karl Popper argues that a scientific theory must be falsifiable, meaning that it should be possible to conceive an event that would prove it wrong. Merely finding confirmations for a theory does not validate it; rather, the strength of a scientific theory lies in its ability to withstand rigorous testing and the potential to be disproven.
In practice
During a lecture on scientific methodology, one can use this quote to illustrate the core principle of falsifiability.
The growth of our knowledge is the result of a process closely resembling what Darwin called 'natural selection'; that is, the natural selection of hypotheses: our knowledge consists, at every moment, of those hypotheses which have shown their (comparative) fitness by surviving so far in their struggle for existence, a competitive struggle which eliminates those hypotheses which are unfit.
If you can't say it simply and clearly, keep quiet, and keep working on it till you can.
No particular theory may ever be regarded as absolutely certain.... No scientific theory is sacrosanct.
The belief in a political Utopia is especially dangerous. This is possibly connected with the fact that the search for a better world, like the investigation of our environment, is (if I am correct) one of the oldest and most important of all the instincts.
A rationalist is simply someone for whom it is more important to learn than to be proved right; someone who is willing to learn from others - not by simply taking over another's opinions, but by gladly allowing others to criticize his ideas and by gladly criticizing the ideas of others
Thus science must begin with myths, and with the criticism of myths; neither with the collection of observations, nor with the invention of experiments, but with the critical discussion of myths, and of magical techniques and practices.
Isolated facts and experiments have in themselves no value, however great their number may be. They only become valuable in a theoretical or practical point of view when they make us acquainted with the law of a series of uniformly recurring phenomena, or, it may be, only give a negative result showing an incompleteness in our knowledge of such a law, till then held to be perfect.
It used to be thought that our genes were historically immutable and that it was not possible to imagine a conversation between culture and genetics.
A research problem is not solved by apparatus; it is solved in a man's head.
Science tells us more and more now that there is a strong connection between emotional well-being and health outcomes, and that you can proactively cultivate emotional well-being through relatively simple practices like sleep, social connection and meditation.
In any finite region of space, matter can only arrange itself in a finite number of configurations, just as a deck of cards can be arranged in only finitely many different orders. If you shuffle the deck infinitely many times, the card orderings must necessarily repeat.
We do not know what the rules of the game are; all we are allowed to do is to watch the playing. Of course, if we watch long enough, we may eventually catch on to a few of the rules. The rules of the game are what we mean by fundamental physics.
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