The ride to orbit was impressive, as it always is. But once I got on board the space station, it really felt like I was visiting an old home; it felt very comfortable.

We didn't build the interstate system to connect New York to Los Angeles because the West Coast was a priority. No, we webbed the highways so people can go to multiple places and invent ways of doing things not thought of by the persons building the roads.

Our observation of nature must be diligent, our reflection profound, and our experiments exact. We rarely see these three means combined; and for this reason, creative geniuses are not common.

Astronomy leads us to a unique event, a universe which was created out of nothing, and delicately balanced to provide exactly the conditions required to support life. In the absence of an absurdly improbable accident, the observations of modern science seem to suggest an underlying, one might say, supernatural plan.

I have not been able to discover the cause of those properties of gravity from phenomena, and I frame no hypotheses; for whatever is not deduced from the phenomena is to be called a hypothesis, and hypotheses, whether metaphysical or physical, whether of occult qualities or mechanical, have no place in experimental philosophy.

Economics profession, they've been - they've been confident in various formulas, but economics is not physics. The same formula that works in one decade doesn't work in the next. Economics is a difficult subject.