One of the biggest concerns about going out beyond lower Earth orbit is the radiation. We find that exercise seems to counteract a lot of the negative effects of space flight, like bone loss and muscle atrophy and cardiovascular systems issues. We exercise two hours a day on the station, which is a huge hit out of your day. It's great for staying in shape, but you know, it cuts into the productivity of the crew and if you look at how expensive it is to get a crew into space, if we can keep them healthy and have them exercise, but spend less time doing it, we can get more done.
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