It is simply no longer possible to believe much of the clinical research that is published, or to rely on the judgment of trusted physicians or authoritative medical guidelines. I take no pleasure in this conclusion, which I reached slowly and reluctantly over my two decades as an editor of The New England Journal of Medicine.
A review of seventy-four clinical trials of antidepressants, for example, found that thirty-seven of thirty-eight positive studies [that praised the drugs] were published. But of the thirty-six negative studies, thirty-three were either not published or published in a form that conveyed a positive outcome.
Interpretation
What this quote means
The quote highlights the bias in publishing clinical trial results regarding antidepressants.
Marcia Angell's quote emphasizes the significant issue of publication bias in clinical research, specifically concerning antidepressants. It reveals that a majority of studies showing positive results are published, while negative results are often hidden or manipulated to appear favorable. This problem undermines the integrity of scientific research and can lead to misleading conclusions about the effectiveness of treatments, ultimately affecting patient care and trust in medical science.
Themes
In practice
Example use cases
This quote can be used in a discussion about the ethics of pharmaceutical research.
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