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Today we have big, crude instruments guided by intelligent surgeons, and we have little, stupid molecules of drugs that get dumped into the body, diffuse around and interfere with things as best they can. At present, medicine is unable to heal anything.

People who don't take risks generally make about two big mistakes a year. People who do take risks generally make about two big mistakes a year.

My number one rule is to keep that camera rolling. Even if it's shaky or slightly out of focus, I don't give a rip. Even if a big old alligator is chewing me up I want to go down and go, 'Crikey!' just before I die. That would be the ultimate for me.

Sex in space (Earth included) far exceeds our wildest imaginations, and is more than a big bang, that's for sure, it's cosmic.

Welcome those big, sticky, complicated problems. In them are your most powerful opportunities.

I am a big fan of Adam Sandler and Ben Stiller, who have carved a niche for themselves. I think doing different kind of films gives you longevity and the ability to set yourself apart.

Sustainability is now a big baggy sack in which people throw all kinds of old ideas, hot air and dodgy activities in order to be able to greenwash their products and feel good.

Why did Nature create man? Was it to show that she is big enough to make mistakes, or was it pure ignorance?

A big mistake people make when they are trying to lose weight is that they stop eating. They'll eat salads once a day and then their body starts trying to protect itself and holds onto the fat.

As Einstein queried, 'Why is it that I get my best ideas in the morning while I'm shaving?' Shaving is like meditation with a sharp object. When the mind is empty and receptive, big ideas flow through every cell of our body. When we're thinking too hard, we tense up and nothing can flow through us; our energy gets stuck in our heads. Sometimes you have to take a leap of faith and trust that if you turn off your head, your feet will take you where you need to go.

Are you willing to take the Big Leap to your ultimate level of success in love, money, and creative contribution?

Eagleton has spent his life inside two mental boxes, Catholicism and Marxism, of both of which he is a severe internal critic—that is, he frequently kicks and scratches at the inside of the boxes, but does not leave them. Neither are ideologies that loosen their grip easily, and people who need the security of adherence to a big dominating ideology, however much they kick and scratch but without daring to leave go, hold on to it every bit as tightly as it holds onto them. The result is of course strangulation, but alas not mutual strangulation: the ideology always wins.

The big nut to crack is to how to tell a story, what’s the right way to tell a particular story.

Thank God life ends—we'd never survive it. From Big Bang to weary shag, the history of the world. Our flesh is ferocious...our bodies will kill us...our bones will outlive us.

Go big, or go home. Otherwise, you’re wasting your youth.

I used to feel more straight for certain months and then just think about boys all the time I'm attracted to women who are very, very boyish. I'm not very big on big mammaries. I have a tendency to be attracted to very, very boyish girls. And usually very feminine men.

In terms of getting people to experiment more and take more risk, there are at least three things that immediately come to my mind. Number one, of course, is role-modeling it yourself. Number two is when people take intelligent, smart risks and yet it doesn't work out, not shooting them. And number three, being honest with yourself. If the culture you have is radically different from an experiment and take-risk culture, then you have a big change you going to have to make—and no little gimmicks are going to do it for you.

Everybody makes such a big deal today about team play because there's such a scarcity of it. Greed is a reason. You have to understand the influence of greed. A player has to be selfish in the pursuit of the development of his skills, but he cannot be selfish when it comes time to blend them in with what's good for his team.

Our world is... longing to see people whose God is big and holy and frightening and gentle and tender... and ours; a God whose love frightens us into His strong and powerful arms where He longs to whisper those terrifying words, 'I love you.'

I don't really remember a time younger than 5 years old that I didn't have skates on because all I can remember is every day, tying up my skates and a big smile on my face, excited to go on the ice.

I get very nervous whenever I think about it. I've never done a serious play, and I have such awe of the woman - she's really my only idol. It's going to be a big stretch - certain people come out on stage and your face muscles automatically tense and you get ready to smile.

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