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Of the many 'firsts' with which I have been involved at the Texas Heart Institute —including the first successful human heart transplant in the United States and the first total artificial heart transplant in the world—the achievement that may have the greatest impact on health care did not occur in the operating room or in the research laboratory. It happened on a piece of paper... when we created the first-ever packaged pricing plan for cardiovascular surgical procedures.

Voting to go on strike is not a decision working people take lightly and is always accompanied by a strong sense of injustice at work. The impact of losing a day's pay is significant, not least for those in the lowest paid jobs who are already on the tightest budgets.

In terms of - my relationship with so many, many young people. I would - I would guess that there are many young people who would come forward. Many more young people who would come forward and say that my methods and - and what I had done for them made a very positive impact on their life. And I didn't go around seeking out every young person for sexual needs that I've helped. There are many that I didn't have - I hardly had any contact with who I have helped in many, many ways.

It really matters whether people are working on generating clean energy or improving transportation or making the Internet work better and all those things. And small groups of people can have a really huge impact.

It’s not a requirement to eat animals, we just choose to do it, so it becomes a moral choice and one that is having a huge impact on the planet, using up resources and destroying the biosphere.

The work is demanding, the impact everlasting. This is no time for 'summer soldiers' in the army of the Lord.

Particularly marijuana, I think is a great hypocrisy. I think frankly it contributes to a good deal of the sense of unfairness you have among younger people who are told they shouldn't do this because it’s got all these negative effects, but then older people are engaging in all kinds of things that probably have a greater impact on people.

I have long been a supporter of the Head Start program because each and every year I witness the dramatic positive impact that early intervention services have on children's lives in my congressional district.

Being rich is a good thing. Not just in the obvious sense of benefitting you and your family, but in the broader sense. Profits are not a zero sum game. The more you make, the more of a financial impact you can have.

How has The Grand Illusion held up over the years? It is not enough to say that it has retained its power. Not only has the stature of the film remained undiminished by the passage of time (except in a few minor details), but the innovation, the audacity, and, for want of a better word, the modernity of the direction have acquired an even greater impact.

In any new situation, whether it involves an elevator or a rocket ship, you will almost certainly be viewed in one of three ways. As a minus one: actively harmful, someone who creates problems. Or as a zero: your impact is neutral and doesn't tip the balance one way or the other. Or you'll be seen as a plus one: someone who actively adds value. Everyone wants to be a plus one, of course. But proclaiming your plus-oneness at the outset almost guarantees you'll be perceived as a minus one, regardless of the skills you bring to the table or how you actually perform.

After all, your chances of winning a lottery and of affecting an election are pretty similar. From a financial perspective, playing the lottery is a bad investment. But it's fun and relatively cheap: for the price of a ticket, you buy the right to fantasize how you'd spend the winnings - much as you get to fantasize that your vote will have some impact on policy.

I do a little fact checking now and then. Other than that its impact is simply that email has revolutionized communication for me, and my website has built up a community of readers, which is a lot of fun.

People need immediate places to refresh, reinvent themselves. Our surroundings built and natural alike, have an immediate and a continuing effect on the way we feel and act, and on our health and intelligence. These places have an impact on our sense of self, our sense of safety, the kind of work we get done, the ways we interact with other people, even our ability to function as citizens in a democracy. In short, the places where we spend our time affect the people we are and can become.

They're kind of baby steps. We haven't made any measurable impact on the mortality rate or survival of this disease.

Global climate change has a profound impact on the survival and development of mankind. It is a major challenge facing all countries.

My most heartfelt thank you goes to Impact Future Media and Cartoon Monkey Studio. Their dedication to the truth is very uncommon in the world we live in today. I am now, and will always be, grateful to their organizations.

More Americans own their home than ever before. Nearly 70 percent of American's are homeowners. So it is a good time for us to asses the positive impacts of homeownership on families, communities and on the nation's economy.

Teamwork remains a sustainable competitive advantage that has been largely untapped because it is hard to measure (teamwork impacts the outcome of an organization in such comprehensive and invasive ways that it's virtually impossible to isolate it as a single variable) and because it is extremely hard to achieve (it requires levels of courage and discipline that few executives possess) - ironically, building a strong team is very simple (it doesn't require masterful insights or tactics).

We expert teachers know that motivation and emotional impact are what matter.

You don't have to wait till your party's in power to have an impact on life at home and around the world.

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