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Using the device of an imaginary world allows me in some strange way to go to the central issues - it's one of many ways to express feelings about real people, about real human relationships.

Hundreds of people are undergoing gene therapy today. There are no known neurological issues.

Issues become much more real to me when I have stories back home.

Gilmore Girls' felt very apart from everything else that was happening. I felt very lucky to be able to be on a show dealing with those issues. I was proud.

Being a thicker post player, and being someone who grew up with self-confidence issues, it's pretty empowering that I've been chosen as this figurehead of basketball in my sport.

Social issues is something I've been a part of changing and pushing for. It's embedded and ingrained in my soul. It's not something that personally I try to plan. It just comes in the heat of the moment.

I have issues with anyone who tries to claim that science is unworkable - creationists who deny evidence for past history, yet are happy to benefit from the products of the methodology that they otherwise deny.

Just so that we are clear on this, I am in favour of teaching children about different beliefs. I am not in favour of indoctrinating them in any particular belief, including my own: these issues should be presented as beliefs, not as fact.

I don't think we should judge celebrities for doing charity work. Period. Whatever their reasons for doing it, they are shedding light on issues that would otherwise go unnoticed.

I'm not afraid to spend money on the R&D that's really going to move us to a cleaner energy source that I think is so much the answer to the issues of environmental responsibility and climate change.

Science fiction stories reflect major issues that concern humanity.

I've really been working on the emotional and internal issues that made me eat in the first place. It's been a real journey.

I have rage and anger issues. So I get mad about stuff in real life, and then I yell about it onstage, and luckily, something funny ends up coming out. What I'll do is tape-record it, and it will end up coming out even funnier. And I add more punch lines.

I like writing about the issues we all bump up against as we get older, but I try to present them in a fun way.

Very often, overweight children have parents who are struggling with weight issues.

I had my issues with the Kardashians, absolutely. I think there's so much wrong with how they are the most revered family in the country, but they are, nevertheless.

I'm pretty middle-of-the-road. There are some issues I'm more conservative on.

In fairness, I don't think that everyone understands what I say, but I think they understand part of it and part of what the issues are... Just the same way that people like a good painting, I think people really like understanding, knowing about the world.

I don't know if my films are about women in a kind of frolicking - here's a grab bag of women's issues. They are about women of substance with very particular stories.

Being a writer can be a very lonely profession, but having a network of people who can sympathize with everything you're going through - from contract issues to the terror of changing your novel from past- to present-tense - is an invaluable asset.

Writers who take on polarising issues are apt to step on a few toes.

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