Hugh Laurie

L.A. runs on optimism, enthusiasm and flattery. I think you can go a little bit crazy. I've heard people say there's a limit to the number of years you can stay in this city without going slightly mad. It's just too damn sunny in every dimension - weather-wise, socially and professionally.

Acting is largely about putting on masks, and music is about removing them.

I know a lot of people think therapy is about sitting around staring at your own navel - but it's staring at your own navel with a goal. And the goal is to one day to see the world in a better way and treat your loved ones with more kindness and have more to give.

As a real person, he wouldn't last a minute, would he? But drama is about imperfection. And we've moved away from the aspirational hero. We got tired of it, it was dull. If I was House's friend, I would hate it. How he so resolutely refuses to be happy or take the kind-hearted road. But we don't always like morally good people, do we?

To tell you the truth, the older I get, the less I know. I keep meeting people, both older and younger, who seem to have accrued so much more knowledge or expertise or certainty about who they are and the jobs they do. I just marvel at it.

I have a reverence for medicine because I hero-worshiped my father [a former doctor], and because I admire doctors, I admire study, empiricism and rational thought. I don't study, empiricize or think rationally myself - but I admire it in others.

I think good-looking people seldom make good television. And American television studios almost concede before they start: 'Well, it won't be good, but at least it'll be good-looking. We'll have nice-looking girls in tight shirts with F.B.I. badges and fit-looking guys with lots of hair gel vaulting over things.'

Music is one of the noblest callings I can think of. It's the highest of all the art forms to me. For example, if my kid said to me, 'I want to give it all up,' whatever it is that they're doing, 'and I want to take my saxophone and go out,' I would say, 'May God go with you. This is a great and noble thing that you're doing.'

Driving a motorcycle is like flying. All your senses are alive. When I ride through Beverly Hills in the early morning, and all the sprinklers have turned off, the scents that wash over me are just heavenly. Being House is like flying, too. You're free of the gravity of what people think.

Death and disaster are at our shoulders every second of our lives, trying to get at us. Missing, a lot of the time. A lot of miles on the motorway without a front wheel blow-out. A lot of viruses that slither through our bodies without snagging. A lot of pianos that fall a minute after we've passed. Or a month, it makes no difference. So unless we're going to get down on our knees and give thanks every time disaster misses, it makes no sense to moan when it strikes.

We put this 15-year old girl on the cover of a fashion magazine, and tell everyone she is the epitome of sexual perfection, but we jail anyone who touches her for another three years.

Success on a cosmic level completely eludes me. I'm deeply suspicious of things being too good. It's part of my superstition, I think, to generate pain in order to give the illusion of gain. I'm not saying I reject success, but honestly, I don't quite know how to deal with it. It's an old feeling: As soon as you have the thing you've been going after all your life, that reasonable degree of security, you start kicking against it, doubting it.