L.A. runs on optimism, enthusiasm and flattery. I think you can go a little bit crazy. I've heard people say there's a limit to the number of years you can stay in this city without going slightly mad. It's just too damn sunny in every dimension - weather-wise, socially and professionally.

Acting is largely about putting on masks, and music is about removing them.

As a real person, he wouldn't last a minute, would he? But drama is about imperfection. And we've moved away from the aspirational hero. We got tired of it, it was dull. If I was House's friend, I would hate it. How he so resolutely refuses to be happy or take the kind-hearted road. But we don't always like morally good people, do we?

To tell you the truth, the older I get, the less I know. I keep meeting people, both older and younger, who seem to have accrued so much more knowledge or expertise or certainty about who they are and the jobs they do. I just marvel at it.

I have a reverence for medicine because I hero-worshiped my father [a former doctor], and because I admire doctors, I admire study, empiricism and rational thought. I don't study, empiricize or think rationally myself - but I admire it in others.

I think good-looking people seldom make good television. And American television studios almost concede before they start: 'Well, it won't be good, but at least it'll be good-looking. We'll have nice-looking girls in tight shirts with F.B.I. badges and fit-looking guys with lots of hair gel vaulting over things.'