If we think of our chromosomes - they carry our genetic material - as being like shoelaces, I work on the plastic tips at the end that protect them.
Interpretation
Blackburn compares chromosomes to shoelaces, emphasizing the importance of their protective ends.
In this quote, Elizabeth Blackburn uses an analogy between chromosomes and shoelaces to illustrate her work on telomeres, which are the protective caps at the ends of chromosomes. Just as plastic tips prevent shoelaces from fraying, telomeres protect our genetic material from deterioration, highlighting the crucial role they play in maintaining the integrity of our DNA and overall cellular health.
In practice
In a lecture about genetics, you could use this quote to illustrate the importance of telomeres in DNA protection.
Cancer cells have had so many other things go wrong with them, genetic, non-genetic changes, that those cells, one of the things they then get selected for is that they have lots of telomerase because now the telomeres in those cells get maintained.
We and other groups are seeing clear statistical links between telomere shortness and risk for a variety of diseases that are becoming very common, such as cardiovascular disease, diabetes and certain cancers.
Checking your telomere length is a bit like weighing yourself: you get this single number which depends on a lot of factors. Telomere length gives a sense of your underlying health.
We think there are lifestyle factors that boost telomerase naturally.
For me, arguably the story of telomeres and telomerase began thousands of years ago, in the cornfields of the Maya highlands of Central America.
Being senior enough in the field, having enough solidity, I don't feel afraid of being marginalized.
Quantum mechanics is certainly imposing. But an inner voice tells me that this is not yet the real thing. The theory says a lot, but does not bring us any closer to the secrets of the "Old One." I, at any rate, am convinced that He is not playing at dice.
Economic and technical imperatives - not any preconceived directives - will keep propelling the process of energy transition.
The most complex object in the known universe: brain, only uses 20 watts of power. It would require a nuclear power plant to energize a computer the size of a city block to mimic your brain, and your brain does it with just 20 watts. So if someone calls you a dim bulb, that's a compliment.
The popularisation of scientific doctrines is producing as great an alteration in the mental state of society as the material applications of science are effecting in its outward life. Such indeed is the respect paid to science, that the most absurd opinions may become current, provided they are expressed in language, the sound of which recals [sic] some well-known scientific phrase.
In science it often happens that scientists say, 'You know that's a really good argument; my position is mistaken,' and then they would actually change their minds and you never hear that old view from them again. They really do it. It doesn't happen as often as it should, because scientists are human and change is sometimes painful. But it happens every day. I cannot recall the last time something like that happened in politics or religion.
As those who have seen Jurassic Park will know, this means a tiny disturbance in one place, can cause a major change in another. A butterfly flapping its wings can cause rain in Central Park, New York. The trouble is, it is not repeatable. The next time the butterfly flaps its wings, a host of other things will be different, which will also influence the weather. That is why weather forecasts are so unreliable.
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