Tout est poison, rien n'est poison, tout est une question de dose. Everything is poisonous, nothing is poisonous, it is all a matter of dose.
Claude BernardRead
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Tout est poison, rien n'est poison, tout est une question de dose. Everything is poisonous, nothing is poisonous, it is all a matter of dose.
To crank myself up I stood on a jack and ran myself up. I tightened myself like a bolt. I inserted myself in a vise-clamp and wound the handle till the pressure built. I drank coffee in titrated doses. It was a tricky business, requiring the finely tuned judgment of a skilled anesthesiologist. There was a tiny range within which coffee was effective, short of which it was useless, and beyond which, fatal.
...This large and expensive stock of drugs will be unnecessary. By...doses of...medicines...multiplying...combining them properly, 20 to 30 articles, aided by the common resources of the lancet, a garden, a kitchen, fresh air, cool water, exercise, will be sufficient to cure all the diseases that are at present under the power of medicine.
All things are poisons, for there is nothing without poisonous qualities. It is only the dose which makes a thing poison.
We used to think that you could spend your way out of a recession and increase employment by cutting taxes and boosting government spending. I tell you in all candour that that option no longer exists, and in so far as it ever did exist, it only worked on each occasion since the war by injecting a bigger dose of inflation into the economy, followed by a higher level of unemployment as the next step.
Realism; fatalism; phlegm. To live in the Fens is to receive strong doses of reality. The great flat monotony of reality; the wide empty space of reality. Melancholia and self-murder are not unknown in the Fens. Heavy drinking, madness and sudden acts of violence are not uncommon. How do you surmount reality, children? How do you acquire, in a flat country, the tonic of elevated feelings?
Half the night I waste in sighs, Half in dreams I sorrow after The delight of early skies; In a wakeful dose I sorrow For the hand, the lips, the eyes, For the meeting of the morrow, The delight of happy laughter, The delight of low replies.
The perfection preached in the gospels never yet built an empire. Every man of action has a strong dose of egotism, pride, hardness, and cunning.
From the point of view of the pharmaceutical industry, the AIDS problem has already been solved. After all, we already have a drug which can be sold at the incredible price of $8,000 an annual dose, and which has the added virtue of not diminishing the market by actually curing anyone.
Ketut, why is life all crazy like this?" I asked my medicine man the next day...So what can we do about the craziness of the world?" Nothing." Ketut laughed, but with a dose of kindness. "This is nature of world. This is destiny. Worry about your craziness only-make you in peace.
It's important, according to me, to train in small doses so as to not lose the joy of playing chess. I personally think too many coaching and training classes may take away a child's interest in the game itself. The essential thing to do is practise often and, in case of a doubt, to consult a trainer.
You know, the cure for all this talk is really a good dose of incompetent government. You get that alternative and you'll never put Singapore together again: Humpty Dumpty cannot be put together again... my asset values will disappear, my apartments will be worth a fraction of what they were, my ministers' jobs will be in peril, their security will be at risk and their women will become maids in other people's countries, foreign workers.
Nothing goes so well with a hot fire and buttered crumpets as a wet day without and a good dose of comfortable horrors within. The heavier the lashing of the rain and the ghastlier the details, the better the flavour seems to be.
Whipping and abuse are like laudanum: you have to double the dose as the sensibilities decline.
He [Washington] has often declared to me that he considered our new constitution as an experiment on the practicability of republican government, and with what dose of liberty man could be trusted for his own good; that he was determined the experiment should have a fair trial, and would lose the last drop of his blood in support of it. And these declarations he repeated to me the oftener and the more pointedly.
Cancer has given me a dose of humility. I'm much more empathetic. It's a club I would rather not have joined, but it is a club.
We have used the Bible as if it were a mere special constable's handbook, an opium dose for keeping beasts of burden patient while they are overloaded.
Adversity in immunological doses has its uses; more than that crushes.
I've told the kids in the ghettos that violence won't solve their problems, but then they ask me, and rightly so; "Why does the government use massive doses of violence to bring about the change it wants in the world?" After this I knew that I could no longer speak against the violence in the ghettos without also speaking against the violence of my government.
In 30 years of travel and training leaders -164 nations - I've never met anyone who didn't need massive doses of love.
These days I must take the world in small and carefully measured doses. It is a sort of homeopathic cure I am undergoing, though I am not certain what this cure is meant to mend. Perhaps I am learning to live amongst the living again. Practising, I mean. But no, that is not it. Being here is just a way of not being anywhere.
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