Tout est poison, rien n'est poison, tout est une question de dose. Everything is poisonous, nothing is poisonous, it is all a matter of dose.
Claude BernardRead
It is impossible to devise an experiment without a preconceived idea; devising an experiment, we said, is putting a question; we never conceive a question without an idea which invites an answer. I consider it, therefore, an absolute principle that experiments must always be devised in view of a preconceived idea, no matter if the idea be not very clear nor very well defined.
Interpretation
Experiments are based on preconceived ideas, as they stem from questions that need answers.
Claude Bernard emphasizes that the foundation of any scientific experiment is rooted in a preconceived idea or hypothesis. He contends that when we formulate questions to investigate, those questions inherently arise from existing ideas, even if they are not fully formed. This highlights the interplay between thought and inquiry in the scientific method.
In practice
This quote can be used to emphasize the necessity of having a hypothesis in science classes.
Tout est poison, rien n'est poison, tout est une question de dose. Everything is poisonous, nothing is poisonous, it is all a matter of dose.
When a physician is called to a patient, he should decide on the diagnosis, then the prognosis, and then the treatment. ... Physicians must know the evolution of the disease, its duration and gravity in order to predict its course and outcome. Here statistics intervene to guide physicians, by teaching them the proportion of mortal cases, and if observation has also shown that the successful and unsuccessful cases can be recognized by certain signs, then the prognosis is more certain.
The goal of scientific physicians in their own science ... is to reduce the indeterminate. Statistics therefore apply only to cases in which the cause of the facts observed is still indeterminate.
Theories are like a stairway; by climbing, science widens its horizon more and more, because theories embody and necessarily include proportionately more facts as they advance.
True science teaches us to doubt and, in ignorance, to refrain.
Now, a living organism is nothing but a wonderful machine endowed with the most marvellous properties and set going by means of the most complex and delicate mechanism.
We keep, in science, getting a more and more sophisticated view of our essential ignorance.
Most of the fundamental ideas of science are essentially simple, and may, as a rule, be expressed in a language comprehensible to everyone.
To stop short in any research that bids fair to widen the gates of knowledge, to recoil from fear of difficulty or adverse criticism, is to bring reproach on science. There is nothing for the investigator to do but go straight on, 'to explore up and down, inch by inch, with the taper his reason;' to follow the light wherever it may lead, even should it at times resemble a will-o'-the-wisp.
Mars once was wet and fertile. It's now bone dry. Something bad happened on Mars. I want to know what happened on Mars so that we may prevent it from happening here on Earth.
Down to their innate molecular core, cancer cells are hyperactive, survival-endowed, scrappy, fecund, inventive copies of ourselves.
It appears that anything you say about the way that theory and experiment may interact is likely to be correct, and anything you say about the way that theory and experiment must interact is likely to be wrong.
Subscribe for the occasional hand-picked quote. No noise.