Tout est poison, rien n'est poison, tout est une question de dose. Everything is poisonous, nothing is poisonous, it is all a matter of dose.
Claude BernardRead
It is impossible to devise an experiment without a preconceived idea; devising an experiment, we said, is putting a question; we never conceive a question without an idea which invites an answer. I consider it, therefore, an absolute principle that experiments must always be devised in view of a preconceived idea, no matter if the idea be not very clear nor very well defined.
Interpretation
Experiments are based on preconceived ideas, as they stem from questions that need answers.
Claude Bernard emphasizes that the foundation of any scientific experiment is rooted in a preconceived idea or hypothesis. He contends that when we formulate questions to investigate, those questions inherently arise from existing ideas, even if they are not fully formed. This highlights the interplay between thought and inquiry in the scientific method.
In practice
This quote can be used to emphasize the necessity of having a hypothesis in science classes.
Tout est poison, rien n'est poison, tout est une question de dose. Everything is poisonous, nothing is poisonous, it is all a matter of dose.
When a physician is called to a patient, he should decide on the diagnosis, then the prognosis, and then the treatment. ... Physicians must know the evolution of the disease, its duration and gravity in order to predict its course and outcome. Here statistics intervene to guide physicians, by teaching them the proportion of mortal cases, and if observation has also shown that the successful and unsuccessful cases can be recognized by certain signs, then the prognosis is more certain.
The goal of scientific physicians in their own science ... is to reduce the indeterminate. Statistics therefore apply only to cases in which the cause of the facts observed is still indeterminate.
Theories are like a stairway; by climbing, science widens its horizon more and more, because theories embody and necessarily include proportionately more facts as they advance.
True science teaches us to doubt and, in ignorance, to refrain.
Now, a living organism is nothing but a wonderful machine endowed with the most marvellous properties and set going by means of the most complex and delicate mechanism.
I just felt that space was the next thing coming in aviation. It was higher, faster. It had the risk.
For me, it was my first cosmic connection, on par with a first kiss. No other planet looks as unworldly or surreal as Saturn. When you see it floating in the eyepiece of your telescope, you feel as if you've uncovered mystery in the cosmos.
Supervised learning works so well when you have the right data set, but ultimately unsupervised learning is going to be a really important component in building really intelligent systems - if you look at how humans learn, it's almost entirely unsupervised.
When we see the shadow on our images, are we seeing the time 11 minutes ago on Mars? Or are we seeing the time on Mars as observed from Earth now? It's like time travel problems in science fiction. When is now; when was then?
The time has come when scientific truth must cease to be the property of the few, when it must be woven into the common life of the world.
Einstein's theory of gravitation replaced Newton's, but apples did not suspend themselves in mid-air, pending the outcome. And humans evolved from apelike ancestors whether they did so by Darwin's proposed mechanism or by some other yet to be discovered.
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