Darwinism may be a fine theory in other contexts, but in startups, intelligent design works best..

I think anything that requires real global breakthroughs requires a degree of intensity and sustained effort that cannot be done part time, so it's s….

My own answer to the contrarian question is that most people think the future of the world will be defined by globalization, but the truth is that te….

Great tech opportunities happen only once..

In a world of scarce resources, globalization without new technology is unsustainable..

I'm in favor of free trade, but I think if you had to make a choice between having technological progress versus free trade, you had one or the other….

A startup is the largest endeavor over which you can have definite mastery. You can have agency not just over your own life, but over a small and imp….

In the most dysfunctional organizations, signaling that work is being done becomes a better strategy for career advancement than actually doing work ….

Technology is probably the single biggest driver of productivity gains for the developed countries. For example, I think it's much more important tha….

Anti-aging is an extremely under-explored field..

No company has a culture; every company is a culture..

What nerds miss is that it takes hard work to make sales look easy..

If you have technological progress, that will encourage more capitalist system. On the other hand, if you don't, if things are stalled, you end up wi….

As an investor-entrepreneur, I’ve always tried to be contrarian, to go against the crowd, to identify opportunities in places where people are not lo….

Competition is overrated. In practice it is quite destructive and should be avoided wherever possible. Much better than fighting for scraps in existi….

Today's 'best practices' lead to dead ends; the best paths are new and untried..

Every business is successful exactly to the extent that it does something others cannot..

American government is not dominated by engineers, it is dominated by lawyers. Engineers are interested in substance and building things; lawyers are….

It is sort of a bit of a caricature of capitalism, that it's always this zero-sum game where you have winners and losers. Silicon Valley, the technol….

I believe we are in a world where innovation in stuff was outlawed. It was basically outlawed in the last 40 years - part of it was environmentalism,….

You have as much computing power in your iPhone as was available at the time of the Apollo missions. But what is it being used for? It’s being used t….